5,6,7,8-tetrahydrofolate dehydrogenase -->
dihydrofolate reductase
medical dictionary


<cell biology> An enzyme involved in the biosynthesis of folic acid coenzymes, that transfers hydrogen from NADP to dihydrofolate, yielding tetrahydrofolic acid. Inhibitors can be used as antimicrobial and anticancer drugs. Standard source is liver and the enzyme is used to assay dihydrofolate.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

Acronym: DHFR

(11 Mar 2008)