BDNF -->
brain-derived neurotrophic factor
medical dictionary

<growth factor>

Small basic protein purified from pig brain, a member of the family of neurotrophic factors that also includes Nerve Growth Factor and neurotrophin 3.

In contrast to nerve growth factor, brain-derived neurotrophic factor is predominanantly (though not exclusively) localised in the CNS. It supports the survival of primary sensory neurones originating from the neural crest and ectodermal placodes that are not responsive to NGF.

In the brain brain-derived neurotrophic factor has a trophic action on retinal, cholinergic, and dopaminergic neurones, and in the peripheral nervous system it acts on both motor and sensory neurones.

Acronym: BDNF

(12 Dec 1998)