A very common calcium binding motif. A 12 amino acid loop with a 12 amino acid _ helix at either end, providing octahedral co-ordination for the calcium ion.

Members of the family include: aequorin, _ actinin, calbindin, calcineurin, calcyphosin, calmodulin, calpain, calcyclin, iacylglycerol kinase, fimbrin, myosin regulatory light chains, oncomodulin, osteonectin, spectrin, troponin C.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

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