Goodpasture's syndromemedical dictionary


<respiratory medicine, nephrology, syndrome> Also referred to as the more descriptive name, anti-glomerular basement membrane antibody disease.

This autoimmune disease results from severe inflammation in the basement membranes of the glomerulus and the alveolus of the lung. Inflammation occurs due to the formation of antibodies to components of the basement membrane at both sites.

Symptoms include bloody urine, decreased urine output, cough with bloody sputum, weakness, fatigue and weight loss. Hypertension and swelling are also common findings on physical examination.

(27 Sep 1997)