Koshland-Nemethy-Filmer modelmedical dictionary

<biochemistry, chemistry> A model to explain the allosteric form of cooperativity; in this model, in the absence of ligands, the protein exists in only one conformation; upon binding, the ligand induces a conformational change that may be transmitted to other subunits.

Synonyms: Adair-Koshland-Nemethy-Filmer model, induced fit model.

Acronym: KNF model

(05 Mar 2000)