M-CSF -->
macrophage colony-stimulating factor
medical dictionary

<growth factor>

A glycoprotein growth factor that causes the committed cell line to proliferate and mature into macrophages.

A cytokine synthesised by mesenchymal cells that stimulates pluripotent stem cells of bone marrow into differentiating towards the production of monocytes (mononuclear phagocytes).

The compound stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series. It is a disulfide-bonded glycoprotein dimer with a mw of 70 kD and binds to a single class of high affinity receptor which is identical to the product of the c-fms proto-oncogene.

See: colony-stimulating factors.

Chemical name: Colony-stimulating factor 1

Acronym: M-CSF

(12 Dec 1998)