A transcription factor (originally found to switch on transcription of genes for the kappa class of immunoglobulins in B lymphocytes). It is involved in activating the transcription of more than 20 genes in a variety of cells and tissues. NF _B is found in the cytoplasm in an inactive form, bound to the protein I_B. A variety of stimuli, such as tumour necrosis factor, phorbol esters and bacterial lipopolysaccharide activate it, by releasing it from I_B, allowing it to enter the nucleus and bind to DNA. It has two subunits p50 and p65 that bind DNA as a heterodimer. The dimerisation and DNA binding activity are located in N terminal regions of 300 amino acid that are similar to regions in the Rel and dorsal transcription factors.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

Nezelof type of thymic alymphoplasia, nez perces, NF, nf < Prev | Next > NFA, nf-kappa b, NF-kappa B kinase

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