alcaptonuriamedical dictionary

<biochemistry> The excretion of homogentisic acid (alkapton) in the urine due to the congenital absence of the enzyme homogentisate 1,2-dioxygenase.

This enzyme mediates the breakdown of the amino acids phenylalanine and tyrosine. The urine may be quite dark, particularly when allowed to stand.

Origin: Gr. Ouron = urine

(27 Sep 1997)

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