antithrombinmedical dictionary

A plasma glycoprotein that inhibits the proteolytic activity of thrombin such that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis.

Antithrombin III, an antithrombin at present somewhat conjectural and biochemically not well characterised. Deficiency is commonly inherited as an autosomal dominant trait; one of the few known mendelizing disorders to which thrombotic disease occurs.

Normal antithrombin, an antithrombin naturally occurring in blood and certain tissues under normal conditions in contrast to abnormal states or antithrombin from other sources.

(05 Mar 2000)