Cytokines that are chemotactic for leucocytes. The first member of the family was IL-8 interleukin-8) but subsequently many other members have been identified. They can now be sub divided into two groups on the basis of the arrangement of a pair of conserved cysteines: the C x C group includes platelet Factor 4, platelet basic protein, interleukin 8, melanoma growth stimulatory protein, macrophage inflammatory protein 2, the C C group contains

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)