chronic granulomatous diseasemedical dictionary


Chronic granulomatous disease is usually fatal in childhood, in which the production of hydrogen peroxide by phagocytes does not occur because of a lesion in an NADP dependent oxidase.

Catalase negative bacteria are not killed and there is no luminol enhanced chemiluminescence when the cells are tested. The absence of the oxygen dependent killing mechanism is not itself fatal but seriously compromises the primary defense system.

at least three separate lesions can cause the syndrome, the commonest being a defect in plasma membrane cytochrome.

Acronym: CGD

(12 Jan 1998)