colony-stimulating factormedical dictionary

<cell biology> A glycoprotein growth factor that regulates the differentiation of particular cells.

These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically and can exert actions on several lines of progenitor cells, and influence end cell function. These lymphokines induce the maturation and proliferation of white blood cells from the primitive cell types present in bone marrow such as the leucocyte, macrophage and monocyte lines.

These substances can also be made by recombinant DNA technology for use clinically to speed bone marrow recovery typically following chemotherapy.

Acronym: CSF

(18 Jul 2002)