A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). The intensity and duration of symptoms vary greatly from individual to individual.

Pharmacological action: alcohol deterrents.

Chemical name: Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-

(12 Dec 1998)