elongation factormedical dictionary

<biochemistry> Peptidyltransferase components of ribosomes that catalyse formation of the acyl bond between the incoming amino acid residue and the peptide chain.

There are three classes of elongation factor: EF1_ (EF Tu in prokaryotes) binds GTP and aminoacyl tRNA, delivering it to the A site of ribosomes. EF 1_ (EF Ts) helps in regeneration of GTP EF 1_. EF 2 (EF G) binds GTP and peptidyl tRNA and translocates it from the A site to the P site. Diptheria toxin inhibits protein synthesis in eukaryotes by adding an ADP ribosyl group to a modified histidine residue (dipthamide) in elongation factor II.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

Eloesser, Leo, Eloesser procedure, elongate, elongation < Prev | Next > elope, elopement, elops, eloquence

Bookmark with: icon icon icon icon iconword visualiser Go and visit our forums Community Forums