glutathione peroxidasemedical dictionary

<enzyme>

<cell biology> A detoxifying enzyme that eliminates hydrogen peroxide and organic peroxides.

Glutathione is an essential cofactor for the enzyme and its reaction involves the oxidation of glutathione (GSH) to glutathione disulphide (GSSG). The GSSG is then reduced to GSH by glutathione reductase. Glutathione peroxidase, (GPX), has a selenocysteine residue in its active site. Three forms of the enzyme exist: cy toplasmic GPX, plasma GPX and phospholipid hydroperoxide GPX.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)