heparan sulphatemedical dictionary

Constituent of membrane associated proteoglycans. The heparan sulphate binding domain of NCAM is proposed to augment NCAM NCAM interactions, suggesting that cell cell bonds mediated by NCAM may involve interactions between multiple ligands. The putative heparin binding site on NCAM is a 28 aa peptide shown to bind both heparin and retinal cells, as well as to inhibit retinal cell adhesion to NCAM. This strengthens the argument that that this site contributes directly to NCAM mediated cell cell adhesion.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)