interleukin-6medical dictionary


A cytokine that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas.

It is produced by many different cells including T-cells, monocytes, and fibroblasts. A single chain 25 kD cytokine originally described as a pre B-cell growth factor, now known to have effects on a number of other cells including T-cells which are also stimulated to proliferate.

An inducer of acute phase proteins and a colony-stimulating factor acting on mouse bone marrow.

Acronym: IL-6

(12 Dec 1998)