lecithin acyltransferase -->
lecithin-cholesterol acyltransferase
medical dictionary


<cell biology> An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesterol ester; a deficiency of this enzyme leads to an accumulation of unesterified cholesterol in plasma resulting in anaemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in individuals with fish-eye disease.

Synonyms: lecithin acyltransferase.

Acronym: LCAT

(05 Mar 2000)