maturation-promoting factormedical dictionary

<enzyme>

<cell biology> A protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms.

In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by cyclins, maturation-promoting factor directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins.

The catalytic subunit of maturation-promoting factor is protein p34cdc2.

Acronym: MPF

(12 Dec 1998)

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