mixed lymphocyte reactionmedical dictionary

<investigation>

<haematology, immunology> Reaction of mitogenesis produced in T lymphocytes when allogeneic (i.e. Mixed) lymphocytes are brought together, provided they are mismatched in histocompatibility loci. Once used as a test for possible graft compatibility in human grafting. Now known that a negative reaction is a poor predictor of graft acceptance.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)