phosphatidylcholinemedical dictionary

<biochemistry> The major phospholipid of most mammalian cell membranes where the 1 acyl residue is normally saturated and the 2 acyl residue unsaturated.

Choline is attached to phosphatidic acid by a phosphodiester linkage. Major synthetic route is from diacyl glycerol and CDP choline. Forms monolayers at an air water interface and forms bilayer structures (liposomes) if dispersed in aqueous medium. A zwitterion over a wide pH range. Readily hydrolysed in dilute alkali.

(31 Dec 1997)