proton pump inhibitormedical dictionary

<pharmacology> A group of anti-ulcer medications which work by binding to H+/K+ ATPase, an enzyme which is found on the secretory surface of parietal cells. It thereby inhibits the final transport of hydrogen ions (via exchange with potasium) into the gastric lumen.

Examples of proton pump inhibitors include omeprazole and lansoprazole.

(27 Sep 1997)

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