voltage clampmedical dictionary

<physiology, technique> A technique in electrophysiology, in which a microelectrode is inserted into a cell and current injected through the electrode so as to hold the cells membrane potential at some predefined level.

The technique can be used with separate electrodes for voltage sensing and current passing, for small cells, the same electrode can be used for both. Voltage clamp is a powerful technique for the study of ion channels.

See: patch clamp.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)